Drug Groups

approved

Description

A local anesthetic that is similar pharmacologically to lidocaine. Currently, it is used most often for infiltration anesthesia in dentistry. (From AMA Drug Evaluations Annual, 1992, p165)

Indication

Used as a local anaesthetic and is often used in dentistry.

Pharmacology

Prilocaine binds to the intracellular surface of sodium channels which blocks the subsequent influx of sodium into the cell. Action potential propagation and never function is, therefore, prevented. This block is reversible and when the drug diffuses away from the cell, sodium channel function is restored and nerve propagation returns.

Affected Organisms

Protein Binding

98%

Elimination

Prilocaine is metabolized in both the liver and the kidney and excreted via the kidney.

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