Drug Groups

approved

Description

A synthetic progestational hormone with actions similar to those of progesterone but functioning as a more potent inhibitor of ovulation. It has weak estrogenic and androgenic properties. The hormone has been used in treating amenorrhea, functional uterine bleeding, endometriosis, and for contraception. [PubChem]

Indication

For use as an oral contraceptive in the prevention of pregnancy.

Pharmacology

Norethindrone is a synthetic oral progestin. It is used for contraception or to treat such conditions as secondary amenorrhea, abnormal uterine bleeding, and endometriosis. As an oral contraceptive, norethindrone is available as either a single agent or in combination with an estrogen.

Affected Organisms

Biotransformation

Hepatic

Absorption

Absolute oral bioavailability approximately 64%

Half Life

7 hours

Protein Binding

>95%

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