Drug Groups

approved

Description

Butoconazole is an imidazole antifungal used in gynecology.

Indication

For the local treatment of vulvovaginal candidiasis (infections caused by Candida)

Pharmacology

Butoconazole is an imidazole derivative that has fungicidal activity in vitro against Candida spp. and has been demonstrated to be clinically effective against vaginal infections due to Candida albicans. Candida albicans has been identified as the predominant species responsible for vulvovaginal candidasis.

Toxicity

Oral, rat: LD₅₀ = >1720 mg/kg.

Affected Organisms

Absorption

Following vaginal administration of butoconazole nitrate vaginal cream, 2% to 3 women, 1.7% (range 1.3-2.2%) of the dose was absorbed on average.

External Links