Drug Groups

approved

Description

Drotaverine (INN, also known as drotaverin) is an antispasmodic drug, structurally related to papaverine. Drotaverine is a selective inhibitor of phosphodiesterase 4, and has no anticholinergic effects. Drotaverine has been shown to possess dose-dependant analgesic effects in animal models. One small study has shown drotaverine to be eliminated mainly non-renally.

Indication

Used in the treatment of functional bowel disorders and alleviating pain in renal colic.

Pharmacology

Drotaverine is a spasmolytic agent by inhibiting PDE4 in smooth muscle cells.

Affected Organisms

Biotransformation

Hepatic

Absorption

Bioavailability is highly variable

Half Life

7 to 12 hours

Protein Binding

80 to 95%

References

External Links