物质信息
ID:4510
名称和标识
别名
Ticrynafen(2,3-Dichloro-4-(2-thenoyl)phenoxy)acetic acid4-(2-Thienylketo)-2,3-dichlorophenoxyacetic acidAcido tienilico [inn-spanish]Thienylic acidTienilico acido [spanish](2,3-Dichloro-4-(2-thiophenecarbonyl)phenoxy)acetic acid(2,3-Dichloro-4-(2-thienylcarbonyl)phenoxy)acetic acidAcidum tienilicum [inn-latin]Tienilic acid4-(2-Theonyl)-2,3-dichlorphenoxyessigsaeure [German]Acide tienilique [inn-french]
商标名
SelacrynDiflurexTicrex
IUPAC传统名
2,3-dichloro-4-(thiophene-2-carbonyl)phenoxyacetic acid
IUPAC标准名
2-[2,3-dichloro-4-(thiophene-2-carbonyl)phenoxy]acetic acid
化合物性质
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描述信息
Drug Groups
withdrawn
Description
Ticrynafen, or tienilic acid, is a diuretic drug with uric acid-lowering (uricosuric) action, formerly marketed for the treatment of hypertension. It was withdrawn in 1982, shortly after its introduction to the market, after case reports in the United States indicated a link between the use of ticrynafen and hepatitis. (Manier et al., 1982)
Indication
For the treatment of hypertension.
Affected Organisms
Humans and other mammals
References
•
Manier JW, Chang WW, Kirchner JP, Beltaos E: Hepatotoxicity associated with ticrynafen--a uricosuric diuretic. Am J Gastroenterol. 1982 Jun;77(6):401-4.
[Pubmed]
External Links
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参考文献
• Manier JW, Chang WW, Kirchner JP, Beltaos E: Hepatotoxicity associated with ticrynafen--a uricosuric diuretic. Am J Gastroenterol. 1982 Jun;77(6):401-4. Pubmed