物质信息

ID:449863

名称和标识
IUPAC标准名
(3R)-3-amino-1-[3-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
别名
MK-0431Sitagliptin
IUPAC传统名
(3R)-3-amino-1-[3-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
数据登录号
化合物性质
药理学性质
生物活性机理
Dipeptidyl peptidase-4 (DPP-4) inhibitor
产品相关信息
应用领域
Antidiabetic drug
描述信息
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分子图谱
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参考文献
• Herman GA; Stevens C, Van Dyck K, Bergman A, Yi B, De Smet M, Snyder K, Hilliard D, Tanen M, Tanaka W, Wang AQ, Zeng W, Musson D, Winchell G, Davies MJ, Ramael S, Gottesdiener KM, Wagner JA.
• "Pharmacokinetics and pharmacodynamics of sitagliptin, an inhibitor of dipeptidyl peptidase IV, in healthy subjects: results from two randomized, double-blind,
• placebo-controlled studies with single oral doses". Clin Pharmacol Ther 78 (6): 675?8. (December 2005)
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