物质信息
ID:449849
名称和标识
IUPAC标准名
1-[1-(1-benzothiophen-2-yl)ethyl]-1-hydroxyurea
别名
ZYFLOLeutrolZileutonZyflo CR
IUPAC传统名
1-[1-(1-benzothiophen-2-yl)ethyl]-1-hydroxyurea
数据登录号
CAS号
化合物性质
药理学性质
生物活性机理
inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation
weak inhibitor of CYP 1A2
5-Lipoxygenase (5-LOX) inhibitor
产品相关信息
应用领域
Antiinflammatory agent
Antiallergic
Investigated for treatment of irritable bowel disease
Potential antiasthmatic agent
描述信息
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分子图谱
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参考文献
• Drug Metab Dispos. 2003 Nov;31(11):1352-60.
• Pulm Pharmacol. 1994 Apr;7(2):73-9
• 2. Lu P, Schrag ML, Slaughter DE, Raab CE, Shou M, Rodrigues AD. Mechanism-based inhibition of human liver microsomal cytochrome P450 1A2 by zileuton, a 5-lipoxygenase inhibitor.
• 1. Malo PE, Bell RL, Shaughnessy TK, Summers JB, Brooks DW, Carter GW. The 5-lipoxygenase inhibitory activity of zileuton in in vitro and in vivo models of antigen-induced airway anaphylaxis.