物质信息
ID:449817
名称和标识
别名
BloqueinaSvedocainBupivacaineCarbostesinNarcainMarcaineSensorcaineDuracaineMeaverin-ultra
IUPAC标准名
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
IUPAC传统名
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
数据登录号
CAS号
化合物性质
产品相关信息
应用领域
Local anaesthetic
药理学性质
生物活性机理
presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse, and by reducing the rate of rise of the action potential
Blocks the generation and the conduction of nerve impulses,
描述信息
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分子图谱
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参考文献
• Wiklund, L., Acta Anaesthesiol. Scand., Suppl., 1978, 70, 83, (rev, pharmacol)
• McClellan, K.J. et al., Drugs, 1998, 56, 355-363, (rev)
• U.K. Pat., 1968, 1 180 712; CA, 73, 25314, (resoln)
• Sorbera, L.A. et al., Drugs of the Future, 1998, 23, 838-842, (rev)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, BOO000; BOO250; BSI250; BOO500
• Wilson, T.D., Anal. Profiles Drug Subst., 1990, 19, 59, (rev)
• Csregh, I., Acta Cryst. C, 1992, 48, 1794, (cryst struct)
• Aps, C. et al., Br. J. Clin. Pharmacol., 1978, 6, 63, (pharmacol)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 1003
• Slot, H.J.B. et al., Acta Cryst. B, 1990, 46, 842, (cryst struct)
• Mangin, P. et al., J. Anal. Toxicol., 1987, 11, 27, (hplc)
• U.K. Pat., 1969, Sterling, 1 166 802; CA, 72, 43429, (synth)
• Tullar, B.F., J. Med. Chem., 1971, 14, 891, (resoln)
• Moore, D.C. et al., Acta Anaesthesiol. Scand., 1977, 21, 109, (rev)
• Jones, G.P. et al., J.C.S. Perkin 2, 1987, 415, (struct, conformn)
• Gristwood, R.W. et al., Expert Opin. Invest. Drugs, 1999, 8, 861-876, (rev)
• Foster, R.H. et al., Drugs, 2000, 59, 551-579, (rev)