物质信息
ID:449766
名称和标识
别名
Estradiol
IUPAC传统名
(1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.02,7.011,15]heptadeca-2(7),3,5-triene-5,14-diol
IUPAC标准名
(1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.02,7.011,15]heptadeca-2(7),3,5-triene-5,14-diol
数据登录号
CAS号
化合物性质
产品相关信息
生物来源
Isol. from ovaries and pregnancy urine.
Sex pheromone for mallard ducks
应用领域
Estradiol (and its semisynthetic esters) are used in estrogen replacement therapy
The most potent of the natural estrogens
药理学性质
生物活性机理
Estradiol enters cells freely and interacts with a cytoplasmic target cell receptor.
The mRNA interacts with ribosomes to produce specific proteins that express the effect of estradiol upon the target cell.
When the estrogen receptor has bound its ligand it can enter the nucleus of the target cell, and regulate gene transcription which leads to formation of messenger RNA.
描述信息
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参考文献
• Tsukuda, Y. et al., J.C.S.(B), 1968, 1387, (cryst struct)
• Miki, T. et al., Proc. Chem. Soc., London, 1963, 139, (synth)
• Ohrt, J.M. et al., Acta Cryst., 1964, 17, 1611, (cryst struct, derivs)
• Wittstruck, T.A. et al., J.O.C., 1973, 38, 1542, (cmr)
• Eder, U. et al., Chem. Ber., 1976, 109, 2948, (synth)
• IARC Monog., 1979, 21, 279, (tox, rev)
• Collins, M.A. et al., Tet. Lett., 1995, 36, 4467, (synth)
• Hylarides, M.D. et al., J.O.C., 1984, 49, 2744, (synth)
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 1455
• Schneider, G. et al., Annalen, 1988, 679, (3-Me ether, synth, pmr, cmr, ir)
• Salole, E.G. et al., Anal. Profiles Drug Subst., 1986, 15, 283, (rev)
• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 3, 565A; 589B; 600B, (nmr)
• Marker, R.E., J.A.C.S., 1938, 60, 2927, (synth)
• Larner, J.M. et al., Endocrinology (Baltimore), 1985, 117, 1209, (metab)
• Busetta, B. et al., Acta Cryst. B, 1976, 32, 1290, (cryst struct)
• Quinkert, G. et al., Annalen, 1981, 2335; 1982, 1999, (synth)
• Ponold, K. et al., Pharmazie, 1973, 28, 371; 1977, 32, 598; 1979, 34, 2050, (STS 153)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 7th edn., Akademie-Verlag, 1994, 6627, (synonyms)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, BFV325; EDO000; EDP000; EDR000; EDS100; DAZ115; EDO500; EDR500
• Aldrich Library of FT-IR Spectra, 1st edn., 1985, 2, 1055C, (ir)
• Gibson, H. et al., Tet. Lett., 1966, 2321, (synth)