物质信息
ID:449736
名称和标识
IUPAC标准名
3-(4-aminophenyl)-3-ethylpiperidine-2,6-dione
别名
AminoglutethimideCytadrenEliptenOrimeten
IUPAC传统名
3-(4-aminophenyl)-3-ethylpiperidine-2,6-dione
数据登录号
CAS号
化合物性质
产品相关信息
应用领域
Now used as aromatase inhibitor for treatment of breast cancer in postmenopausal women and for treatment of secondary hyperaldosteronism and oedema
Originally used as anticonvulsant, withdrawn due to adrenotoxicity.
Inhibits adrenal corticosteroid synthesis
药理学性质
生物活性机理
Aromatase inhibitor
Corticosteroid antagonist
Cholesterol desmolase inhibitor
Mineralocorticoid synthesis inhibitor
Inhibits hydroxylations required for aromatization of androgens to estrogens
Corticosteroid synthesis inhibitor
Androgen synthesis inhibitor
描述信息
暂无数据
点击上传数据
分子图谱
暂无数据
点击上传数据
参考文献
• Defay, N. et al., J. Pharm. Belg., 1972, 27, 335, (pmr)
• Bushell, S.M. et al., Tetrahedron, 1998, 54, 2269-2274, (synth, ir, pmr, cmr)
• Santen, R.J. et al., Pharmanual (Basel), Vol. 2: A Comprehensive Guide to the Therapeutic Use of Aminoglutethimide, Karger, Basel, Switz., 1981, (book)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, AKC600
• Aboul-Enein, H.Y. et al., J. Med. Chem., 1975, 18, 736, (synth, pharmacol)
• Aldrich Library of FT-IR Spectra, 1st edn., 1985, 2, 404A, (ir)
• Ruecker, G. et al., Arch. Pharm. (Weinheim, Ger.), 1969, 302, 204, (ms)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 454
• Salhanick, H.A., Cancer Res., 1982, 42, 3315, (pharmacol)
• Van Roey, P. et al., Acta Cryst. C, 1991, 47, 829, (cryst struct, bibl)
• Chang, M.-Y. et al., Tet. Lett., 2000, 41, 10273-10276, (synth)
• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 2, 1456C, (nmr)
• Lee, C.M. et al., J.A.C.S., 1961, 83, 4586, (uv, ir)
• Aboul-Enein, H.Y., Anal. Profiles Drug Subst., 1986, 15, 35, (rev)