物质信息
ID:449730
名称和标识
别名
ChlothixenTruxalTaractanChlorprothixeneTraquilanTarasan
IUPAC标准名
{3-[(9Z)-2-chloro-9H-thioxanthen-9-ylidene]propyl}dimethylamine
IUPAC传统名
{3-[(9Z)-2-chloro-9H-thioxanthen-9-ylidene]propyl}dimethylamine
数据登录号
CAS号
化合物性质
药理学性质
生物活性机理
H1 : sedation, weight gain
5-HT2 : anxiolysis, antipsychotic effects
Alpha1 : hypotension, tachycardia
D1, D2, D3 : antipsychotic effects
Strong blocking effects at the following postsynaptic receptors:
Muscarinic : anticholinergic side effects, extrapyramidal side effects attenuated
产品相关信息
应用领域
Psychosedative
Neuroleptic
Tranquilliser
Antihistamine
描述信息
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分子图谱
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参考文献
• U.K. Pat., 1960, 829 763; CA, 54, 24811, (synth)
• Biel, J.H., Princ. Psychopharmacol., Academic Press, New York, 1970, 269, (rev, pharmacol)
• de Leenheer, A., J. Assoc. Off. Anal. Chem., 1973, 56, 105, (uv)
• Post, M.L. et al., Acta Cryst. B, 1974, 30, 1644, (cryst struct)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, TAF675
• Kaiser, C. et al., J. Med. Chem., 1974, 17, 131, (pmr)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 4729, (synonyms)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 581
• Rudy, B.C. et al., Anal. Profiles Drug Subst., 1973, 2, 63, (rev)
• Irwin, W.J. et al., Chem. Br., 1982, 708, (hplc)