物质信息
ID:449716
名称和标识
IUPAC标准名
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile
别名
IsoptinIproveratrilBerkatensCordiloxEthimilUniverVasolanVerapressVerapamilCoveraGeanginVerelanSecuronCalan
IUPAC传统名
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile
数据登录号
CAS号
化合物性质
产品相关信息
应用领域
Coronary vasodilator
Used in the treatment of hypertension, angina pectoris, cardiac arrhythmia, and cluster headaches.
Antiarrhythmic (class IV) agent
Smooth muscle relaxant.
药理学性质
生物活性机理
Calcium antagonist
Inhibits movement of calcium ions across the cell membrane
Protein kinase C inhibitor
描述信息
暂无数据
点击上传数据
分子图谱
暂无数据
点击上传数据
参考文献
• Brogden, R.N. et al., Drugs, 1996, 51, 792, (rev)
• Dooley, M. et al., Drugs, 1998, 56, 837-844, (rev)
• Guerrero, J.R. et al., Med. Res. Rev., 1984, 4, 87, (rev)
• Hofer, C.A. et al., Am. J. Med., 1993, 95, 431, (tox)
• Baky, S.H. et al., Pharmacol. Biochem. Prop. Drug Subst., 1981, 3, 226, (rev, pharmacol)
• Knoll, A.G., Angew. Chem., Int. Ed., 1964, 3, 68, (synth, pharmacol)
• Ramuz, H., Helv. Chim. Acta, 1975, 58, 2050, (synth, ir, ms, pmr, abs config)
• Theodore, L.J. et al., J.O.C., 1987, 52, 1309, (synth)
• Larangh, J.H., Am. J. Cardiol., Ed., Part 7, 1986, 57, (book)
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 960
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, IRV000; VHA450
• Longstreth, J.A., Drug Stereochem., (Ed. Wainer, I.W.), M. Dekker, 1993, 315, (rev)
• Carpy, A. et al., Acta Cryst. C, 1985, 41, 624, (cryst struct)
• Chang, Z.L., Anal. Profiles Drug Subst., 1988, 17, 643, (rev)
• Brenna, E. et al., Eur. J. Org. Chem., 2001, 1349-1357, (synth)
• Scheid, W. et al., Arzneim.-Forsch., 1991, 41, 901, (tox)
• Bannister, R.M. et al., Org. Process Res. Dev., 2000, 4, 467-472, (synth, pmr)
• Ger. Pat., 1978, 2 631 222; CA, 88, 169796, (synth)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 7th edn., Akademie-Verlag, 1994, 10669; 10670
• Echizen, H. et al., Clin. Pharmacokinet., 1986, 11, 425, (rev)