物质信息
ID:449705
名称和标识
IUPAC标准名
5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine
别名
TrimethoprimSyraprimTrimpex
IUPAC传统名
5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine
数据登录号
CAS号
化合物性质
药理学性质
生物活性机理
Binding to bacterial enzyme is stronger than to the corresponding mammalian enzyme
Reversible dihydrofolate-reductase-inhibitor
Bacterial biosynthesis of nucleic acids and proteins is blocked by interference with normal bacterial metabolism of folinate
Blocks production of tetrahydrofolate from dihydrofolate
Folate antagonist
产品相关信息
应用领域
Antiseptic
Active against common urinary-tract pathogens except for Pseudomonas aeruginosa
Antibacterial agent
Active against Haemophilus-influenzae.
Inhibits dihydrofolate reductase from bacterial sources and from malaria parasites
描述信息
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分子图谱
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参考文献
• Koetzle, T.F. et al., J.A.C.S., 1976, 98, 2074, (cryst struct)
• Huovinen, P., Antimicrob. Agents Chemother., 1987, 31, 1451, (rev, props)
• Brossi, A. et al., J. Med. Chem., 1971, 14, 462, (synth)
• Bryan, R.F. et al., Acta Cryst. C, 1987, 43, 2412, (cryst struct)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 219
• Burchall, J.J., Antibiotics (N.Y.), 1975, 3, 304, (rev)
• Sigel, C.W., Handb. Exp. Pharmacol., 1983, 64, 163, (rev, metab)
• Roth, B. et al., J. Med. Chem., 1980, 23, 379; 535, (synth)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 7th edn., Akademie-Verlag, 1994, 4092
• Manius, G.J., Anal. Profiles Drug Subst., 1978, 7, 445, (rev, synth, props, anal)
• Brogden, R.N. et al., Drugs, 1982, 23, 405, (rev, pharmacol)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, TKX000; TKZ000