物质信息

ID:449698

名称和标识
IUPAC标准名
3,5-dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
别名
NifedipineNimodrelProcardiaSlofedipineNivatenAdalatAngiopineCorodayFenihidineHypolar RetardGlopirNifelatAdipineCardilateCoractenFortipineNifedicorNifedipressNifedotardNifensar XLTensipineCalanifCalcilatNifecor
IUPAC传统名
3,5-dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
数据登录号
化合物性质
药理学性质
生物活性机理
The decrease in intracellular calcium inhibits the contractile processes of smooth muscle cells,
increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.
Inhibits the influx of extracellular calcium through myocardial and vascular membrane pores by physically plugging the channel
Calcium channel blocker
causing dilation of the coronary and systemic arteries,
产品相关信息
应用领域
Used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon
Coronary vasodilator
Antihypertensive agent
描述信息
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分子图谱
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参考文献
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• Swanson, T.H. et al., Gen. Pharmacol., 1986, 17, 255, (rev)
• Otero, M.L. et al., Drugs, Suppl. 1, 1994, 48, (pharmacol, rev)
• Kurfurst, A. et al., Coll. Czech. Chem. Comm., 1984, 49, 2393, (pmr, cmr)
• Hugenholz, P.G., Handb. Exp. Pharmacol., 1985, 76, 459, (rev)
• Lvai, L. et al., Synth. Commun., 1992, 22, 47, (synth)
• Krebs, R., Treat. Cardiovasc. Dis. Adalat, (Nifedipine), (Ed.), Schatteur, Stuttgart, 1986, (book)
• Ali, S.K., Anal. Profiles Drug Subst., 1989, 18, 221, (rev)
• Vater, W. et al., Arzneim.-Forsch., 1972, 22, 1; 15; 330, (pharmacol)
• Loev, B. et al., J. Med. Chem., 1974, 17, 956, (synth)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 7th edn., Akademie-Verlag, 1994, 5767, (synonyms)
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