物质信息
ID:449697
名称和标识
IUPAC标准名
[2-hydroxy-3-(naphthalen-1-yloxy)propyl](propan-2-yl)amine
别名
1-[(1-Methylethyl)amino]-3-(1-naphthalenyloxy)-2-propanol; 1-Isopropylamino-3-(1-naphthyloxy)-2-propanolPropranolol
IUPAC传统名
[2-hydroxy-3-(naphthalen-1-yloxy)propyl](propan-2-yl)amine
数据登录号
CAS号
化合物性质
产品相关信息
应用领域
Local anesthetic
Hypotensives
Antiarrhythmic agent
药理学性质
生物活性机理
It has little intrinsic sympathomimetic activity (ISA) but has strong membrane stabilizing activity (only at high blood concentrations, eg overdosage).
It is a non-selective beta blocker, that is, it blocks the action of epinephrine on both beta1- and beta2-adrenergic receptors.
Beta-Adrenergic blocking agent
Only L-propranolol is a powerful adrenoceptor antagonist, whereas D-propranolol is not
描述信息
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分子图谱
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参考文献
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• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 2, 633C; 634A, (nmr)
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• Okamoto, Y. et al., Chem. Lett., 1986, 7, 1237, (resoln)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, ICB000; ICC000; PNB790; PNB800
• Thompson, J.A. et al., J. Chromatogr., 1982, 238, 470, (synth, sepn)
• Barrans, Y. et al., Acta Cryst. B, 1973, 29, 1264, (cryst struct)
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• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 638
• Paul, R. et al., J.O.C., 1975, 40, 1653, (abs config)