物质信息
ID:449676
名称和标识
IUPAC标准名
(1-hydroxy-1-phosphonoethyl)phosphonic acid
别名
EtidronateKsidifonEtidronateXidiphone
IUPAC传统名
(1-hydroxy-1-phosphonoethyl)phosphonic acid
数据登录号
CAS号
化合物性质
产品相关信息
应用领域
This medicine is used to treat Paget's Disease, and to treat conditions of irregular bone growth due to hip fracture or spinal cord injury
药理学性质
生物活性机理
Bone resorption inhibitor
Reduces the number of osteoclasts in active bone turnover-sites
Chelator
描述信息
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分子图谱
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参考文献
• Fleisch, H., Bisphosphonates and Tumor Osteolysis, (Brunner, K.W. et al, ed.), Springer-Verlag, Berlin, 1989, 1, (rev)
• Osvath, R., Food Chem. News, 2001, 43(32), 11, (use)
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• Kasparek, F., Monatsh. Chem., 1968, 99, 2016, (synth)
• Pribil, R. et al., Talanta, 1967, 14, 591, (use)
• Afonin, E.G. et al., Zh. Obshch. Khim., 1987, 57, 538; 1989, 59, 317; J. Gen. Chem. USSR (Engl. Transl.), 1987, 57, 469; 1989, 59, 273, (acid, salts, ir)
• Kashina, N.A. et al., Zh. Obshch. Khim., 1992, 62, 1567; J. Gen. Chem. USSR (Engl. Transl.), 1992, 62, 1284, (props)
• Worms, K.H. et al., Z. Anorg. Allg. Chem., 1979, 457, 209, (synth)
• Goeva, L.V., Radiokhimiya, 1982, 22, 591; Sov. Radiochem. (Engl. Transl.), 1982, 22, 489, (props)
• Van der Pol, H.J., Pharm. Weekbl., 1983, 118, 330, (anal, props)
• Motekaitis, R.J. et al., Inorg. Chem., 1980, 19, 1646, (props, complexes)
• Rizhalla, E.N. et al., Talanta, 1980, 27, 715, (complexes)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, DXD400; TEE250; TNL750; HKS780
• Barnett, B.L. et al., Acta Cryst. B, 1979, 35, 1212, (cryst struct)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 658
• Michael, W.R. et al., Toxicol. Appl. Pharmacol., 1972, 21, 503, (metab)
• Collins, A.J. et al., J. Appl. Chem. Biotechnol., 1977, 27, 651, (props, salts)
• Perfil'ev, V.A. et al., Zh. Anal. Khim., 1984, 39, 2133, (detn, V)
• Bikhman, B.I. et al., Zh. Neorg. Khim., 1973, 18, 2406; Russ. J. Inorg. Chem. (Engl. Transl.), 1973, 18, 1273, (ir, salts)
• Encyclopedia of Food and Color Additives, (ed. Burdock, G.A.), CRC Press, 1997, 1371-1372
• Shkol'nikova, L.M. et al., Kristallografiya, 1991, 36, 77; Sov. Phys. Crystallogr. (Engl. Transl.), 1991, 36, 40, (cryst structs)
• Strates, B.S. et al., Biochim. Biophys. Acta, 1971, 244, 121, (pharmacol)
• Wiers, B.H., Inorg. Chem., 1971, 10, 2581, (salts)
• De Angelis, L., Drugs of Today (Barcelona), 1978, 14, 101, (rev, pharmacol)