物质信息
ID:449649
名称和标识
IUPAC标准名
(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
别名
CurcuminDiferuloylmethaneCurcuma yellow
IUPAC传统名
(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
数据登录号
CAS号
化合物性质
产品相关信息
应用领域
Antitumor
Antiarthritic
Antiamyloid
Possesses bactericidal and fungicidal props.
Antiinflammatory agent
Bile stimulant showing hepatoprotective props
生物来源
Isol. from Curcuma zedoaria (turmeric), other Curcuma spp. and other spp.
简要说明
Tautomers
药理学性质
生物活性机理
Inhibitor of eicosanoid biosynthesis
Acts as a free radical scavenger and antioxidant, inhibiting lipid peroxidation and oxidative DNA damage
Induce glutathione S-transferase and are potent inhibitors of cytochrome P450;
描述信息
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分子图谱
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参考文献
• Aldrich Library of FT-IR Spectra, 1st edn., 1985, 2, 52C, (ir)
• Spicer, G.S. et al., Anal. Chim. Acta, 1958, 18, 231, (detn, B)
• Umland, F. et al., Fresenius' Z. Anal. Chem., 1963, 197, 151, (detn, Ni)
• Sastry, B.S., Res. Ind., 1970, 15, 258; CA, 75, 75063e, (isol)
• Quint, P. et al., Fresenius' Z. Anal. Chem., 1977, 285, 356; 1979, 295, 269, (detn, B)
• Roughley, P.J. et al., J.C.S. Perkin 1, 1973, 2379-2388, (biosynth)
• Kashina, C. et al., Heterocycles, 1977, 7, 241, (synth)
• Karig, F., Dtsch. Apoth. -Ztg., 1975, 115, 325; CA, 83, 65372f, (derivs)
• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 2, 800B, (nmr)
• Kuroyagi, M. et al., Yakugaku Zasshi, 1970, 90, 1467; CA, 74, 61612a, (isol)
• Dyrssen, D.W. et al., Anal. Chim. Acta, 1972, 60, 139, (detn, B)
• Lampe, V., Ber., 1918, 51, 1347, (synth)
• Cheng, K.L. et al., Handbook of Organic Analytical Reagents, CRC Press, Boca Raton, 1982, 511, (use)
• Jentzsch, K. et al., Sci. Pharm., 1968, 36, 251; CA, 70, 90793h, (isol)
• Holder, G.M. et al., Xenobiotica, 1978, 8, 761, (metab)
• Ammon, H.P.T. et al., Planta Med., 1991, 57, 1-7, (rev, pharmacol)
• Jitoe, A. et al., J. Agric. Food Chem., 1992, 40, 1337-1340, (occur)
• Wahlstrom, B. et al., Acta Pharmacol. Toxicol., 1978, 43, 86, (metab)
• Srinivasan, K.R., J. Pharm. Pharmacol., 1953, 5, 448, (derivs)
• Tonnesen, H.H. et al., Acta Chem. Scand., Ser. B, 1982, 36, 475, (cryst struct, bibl)