物质信息
ID:449637
名称和标识
IUPAC标准名
(1S,2S,4R,8S,9S,11S,12R,13S)-12-fluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one
别名
Triamcinolone acetonideFluoxiprednisoloneLederspanVolonAristocortKenacort
IUPAC传统名
(1S,2S,4R,8S,9S,11S,12R,13S)-12-fluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one
数据登录号
CAS号
化合物性质
药理学性质
生物活性机理
Glucocorticoid
May produce direct smooth muscle relaxation
Enhances the effect of sympatholytics-beta on cyclic-AMP production
Possible mechanisms: may decrease the number of inflammatory-cells
Exact bronchodilator mechanism unknown
Topical admin
May inhibit bronchoconstrictor mechanisms
Vasoconstrictor
产品相关信息
应用领域
Antiproliferative
Antipruritic
Antiinflammatory agent
描述信息
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分子图谱
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参考文献
• Bernstein, S. et al., J.A.C.S., 1959, 81, 1689, (synth, acetonide)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 739
• Jeal, W. et al., Drugs, 1997, 53, 257-280, (rev, acetonide)
• Fiegel, G., Arzneim.-Forsch., 1975, 25, 560, (rev)
• Fried, J. et al., J.A.C.S., 1958, 80, 2338, (synth, pharmacol)
• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 3, 586B, (nmr)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 6222; 7100; 7152
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, AQX250; AQY375; AQX500; AQX750
• Bernstein, S. et al., J.A.C.S., 1956, 78, 5693, (synth)
• Toft, P. et al., Can. J. Pharm. Sci., 1972, 7, 53, (ms)
• Sieh, D.H., Anal. Profiles Drug Subst., 1982, 11, 593; 615; 651, (rev)
• Florey, K., Anal. Profiles Drug Subst., 1972, 1, 367; 397; 423, (rev)
• Zbinovsky, V. et al., Anal. Profiles Drug Subst., 1977, 6, 579, (rev)
• van Leusen, D. et al., J.O.C., 1994, 59, 7534, (synth, acetonide)