物质信息
ID:449628
名称和标识
IUPAC标准名
2-[(1S,2R,10S,11S,14R,15S)-14-hydroxy-2,15-dimethyl-5,17-dioxotetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-14-yl]-2-oxoethyl acetate
别名
CortancylDelcortinPrednisone acetateDelta-CorlinNisone
IUPAC传统名
2-[(1S,2R,10S,11S,14R,15S)-14-hydroxy-2,15-dimethyl-5,17-dioxotetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-14-yl]-2-oxoethyl acetate
数据登录号
CAS号
化合物性质
产品相关信息
应用领域
Antiinflammatory
Immunosuppressive
生物来源
Obt. from pregn-4-ene-3,11,20-trione by incubation with Corynebacterium simplex
药理学性质
生物活性机理
Glycogen deposition inhibitor
Calcium mobilizer
ACTH secretion inhibitor
Corticosteroid
Gluconeogenesis promoter
Phosphorus mobilizer
ACTH antagonist
描述信息
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分子图谱
暂无数据
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参考文献
• Tseikinskii, V.M. et al., Bioorg. Khim., 1979, 5, 1677, (cryst struct)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 6213
• Gambertoglio, J.G. et al., J. Pharmacokinet. Biopharm., 1980, 8, 1, (rev)
• Pickup, M.E., Clin. Pharmacokinet., 1979, 4, 111, (rev)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, PLZ000; PLZ100
• Nobile, A. et al., J.A.C.S., 1955, 77, 4184, (synth)
• Herzog, H.L. et al., Science (Washington, D.C.), 1955, 121, 176, (struct)
• Herzog, H.L. et al., Tetrahedron, 1962, 18, 581, (synth)
• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 3, 587B, (nmr)
• Gardi, R. et al., Gazz. Chim. Ital., 1963, 93, 431, (ir, uv)
• Hickey, J.P. et al., J. Magn. Reson., 1980, 38, 501, (cmr)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 738