物质信息
ID:449625
名称和标识
IUPAC标准名
4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-1,2-dihydropyrimidin-2-one
别名
EpivirZeffixLamivudine
IUPAC传统名
4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-1,2-dihydropyrimidin-2-one
数据登录号
CAS号
化合物性质
产品相关信息
应用领域
Potent antiviral agent
Active against hepatitis B virus and human immunodeficiency virus
药理学性质
生物活性机理
HIV reverse transcriptase inhibitor
描述信息
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分子图谱
暂无数据
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参考文献
• Beach, J.W. et al., J.O.C., 1991, 56, 6503; 1992, 57, 2217, (synth, bibl, pharmacol)
• Skalski, V. et al., J. Biol. Chem., 1993, 268, 23234, (pharmacol)
• van Leeuwen, R. et al., J. Infect. Dis., 1995, 171, 1166; 1438, (clin trials)
• Perry, C.M. et al., Drugs, 1997, 54, 657-680, (rev)
• Schinazi, R.F. et al., Antimicrob. Agents Chemother., 1992, 36, 672, (pharmacol)
• Chang, C.N. et al., J. Biol. Chem., 1992, 267, 22414, (pharmacol)
• Soudeyns, H. et al., Antimicrob. Agents Chemother., 1991, 35, 1386, (pharmacol)
• Storer, R. et al., Nucleosides Nucleotides, 1993, 12, 225, (synth, abs config)
• Jarvis, B. et al., Drugs, 1999, 58, 101-141
• Eur. Pat., 1992, Glaxo, 517 145; CA, 118, 191756p, (synth, cryst struct)
• Humber, D.C. et al., Tet. Lett., 1992, 33, 4625, (synth, bibl)
• Jeong, L.S. et al., J. Med. Chem., 1993, 36, 181; 2627, (synth, bibl, pharmacol, pmr, uv)
• Coates, J.A.V. et al., Antimicrob. Agents Chemother., 1992, 36, 202, (pharmacol)
• Harris, R.K. et al., J.C.S. Perkin 1, 1997, 2653-2659, (cryst struct, ir, cmr, pmr)
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 622