物质信息
ID:449624
名称和标识
IUPAC标准名
(2S,3aS,6aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-octahydrocyclopenta[b]pyrrole-2-carboxylic acid
别名
AltaceTritaceRamiprilRamaceUniprilPramaceVesdilDelixTriatecQuarkAcovilHypren
IUPAC传统名
(2S,3aS,6aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-octahydrocyclopenta[b]pyrrole-2-carboxylic acid
数据登录号
CAS号
化合物性质
产品相关信息
应用领域
Antihypertensive agent
Hypotensive
简要说明
Isomers (3:1)
药理学性质
生物活性机理
ACE inhibitor
Angiotensin converting enzyme inhibitor
描述信息
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分子图谱
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参考文献
• Omosu, M. et al., Arzneim.-Forsch., 1988, 38, 1309, (pharmacol)
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 941
• Becker, R.H.A. et al., Am. J. Cardiol., 1987, 59, 3D; 18D; 23D, (revs, Ramipril)
• Aboulenein, H.Y. et al., Anal. Lett., 1991, 24, 2217, (detn)
• Meisel, S. et al., Clin. Pharmacokinet., 1994, 26, 7, (rev, pharmacokinet)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 7th edn., Akademie-Verlag, 1994, 9653, (synonyms)
• Eur. Pat., 1983, Hoechst, 79 022; CA, 100, 52012, (synth)
• Ger. Pat., 1989, Hoechst, 3 901 291; CA, 113, 52535z, (synth)
• Paulus, E.F. et al., Acta Cryst. C, 1987, 43, 941, (cryst struct)
• Tabata, S. et al., Arzneim.-Forsch., 1990, 40, 865, (metab)
• J. Cardiovasc. Pharmacol., 1991, 18, Suppl. 2, (rev)
• Frampton, J.E. et al., Drugs, 1995, 49, 440, (rev)