物质信息
ID:449622
名称和标识
IUPAC标准名
(1S,2R,10S,11S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-diene-5,17-dione
别名
Prednisone
IUPAC传统名
(1S,2R,10S,11S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-diene-5,17-dione
数据登录号
CAS号
化合物性质
产品相关信息
应用领域
Antiinflammatory
Immunosuppressive
药理学性质
生物活性机理
Glycogen deposition inhibitor
Corticosteroid
Gluconeogenesis promoter
ACTH secretion inhibitor
Phosphorus mobilizer
Calcium mobilizer
ACTH antagonist
描述信息
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分子图谱
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参考文献
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, PLZ000; PLZ100
• Gambertoglio, J.G. et al., J. Pharmacokinet. Biopharm., 1980, 8, 1, (rev)
• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 3, 587B, (nmr)
• Herzog, H.L. et al., Tetrahedron, 1962, 18, 581, (synth)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 6213
• Ger. Pat., 1960, 1 090 208; CA, 55, 26044b, (sulfate)
• Ger. Pat., 1960, 1 089 755; CA, 55, 20008, (succinate)
• Nobile, A. et al., J.A.C.S., 1955, 77, 4184, (synth)
• Pickup, M.E., Clin. Pharmacokinet., 1979, 4, 111, (rev)
• Herzog, H.L. et al., Science (Washington, D.C.), 1955, 121, 176, (struct)
• Hickey, J.P. et al., J. Magn. Reson., 1980, 38, 501, (cmr)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 738
• Gardi, R. et al., Gazz. Chim. Ital., 1963, 93, 431, (ir, uv)