物质信息
ID:449595
名称和标识
IUPAC标准名
(2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid
别名
CapotenCaptoprilCapaceAcenormAcepril
IUPAC传统名
(2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid
数据登录号
CAS号
化合物性质
产品相关信息
应用领域
Exp. drug for treatment of myocardial infarction
Smooth muscle relaxant
Drug used for diagnosis and treatment of renin-dependent hypertension
Antihypertensive agent
简要说明
Diastereomers
药理学性质
生物活性机理
increases plasma levels of PGE2 and PGE2-alpha metabolites.
increased plasma-renin causes decrease in aldosterone-secretion resulting in: small increases in serum-potassium
ACE inhibitor
apparent primary action involves suppression of the renin-angiotensin-aldosterone-system
increased sodium-excretion
Increases urinary excretion of PGE2
increases plasma-renin activity resulting from loss of negative feedback on renin release due to reduced angiotensin-2 concentration
decrease in plasma-volume
angiotensin-antagonist
decreases plasma-angiotensin-2 concentration
May increase prostaglandin synthesis
May inhibit local angiotensin 2 at vascular and renal sites so attenuating catecholamine release
描述信息
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参考文献
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, MCO750
• Cardoni, A.A. et al., Drug Intell. Clin. Pharm., 1981, 15, 932, (pharmacol, rev)
• Horovitz, Z.P. et al., Pharmacol. Biochem. Prop. Drug Subst., 1981, 3, 148, (pharmacol)
• Migdalof, B.H. et al., Drug Metab. Rev., 1984, 15, 841, (rev)
• Shimazaki, M. et al., Chem. Pharm. Bull., 1982, 30, 3139, (synth)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 1331
• Ger. Pat., 1977, Squibb, 2 703 828; CA, 88, 7376c, (synth)
• Condon, M.E. et al., J. Med. Chem., 1982, 25, 250, (synth)
• Ondetti, M.A. et al., Science (Washington, D.C.), 1977, 196, 441, (use)
• Drummer, O.H. et al., Med. Res. Rev., 1986, 6, 75, (rev, metab)
• Kadin, H., Anal. Profiles Drug Subst., 1982, 11, 79, (synth, prop, detn, pharmacol, rev)
• Bashiardes, C. et al., Tet. Lett., 1987, 28, 5563, (synth)
• Aboul-Enein, H.Y. et al., Spectrosc. Lett., 1985, 18, 419, (pmr, conformn)
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 836
• ACE Inhibitors: Current Use and Future Prospects, (ed. Schachter, M.), Martin Dunitz, London, 1995, (book)