物质信息
ID:449584
名称和标识
IUPAC标准名
(19S)-19-ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione
别名
Camptothecin
IUPAC传统名
(19S)-19-ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione
数据登录号
CAS号
化合物性质
产品相关信息
应用领域
Used clinically in China against gastrointestinal tumours
Shows potent antineoplastic activity in exp. animals
Cytostatic
Severe side effects and rapid hydrol. at physiological pH have inhibited widespread clinical use
Shows plant growth regulatory and insect chemosterilant props.
Shows anti-HIV and antiprotozoal activity
生物来源
Alkaloid from Camptotheca acuminata, Mappia foetida, Ervatamia heyneana and Ophiorrhiza mungos (Nyssaceae, Rubiaceae, Apocynaceae)
药理学性质
生物活性机理
Inhibits the DNA enzyme topoisomerase
描述信息
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分子图谱
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参考文献
• Boch, M. et al., Chem. Ber., 1972, 105, 2126, (synth)
• Sheriha, G.M. et al., Phytochemistry, 1976, 15, 505, (biosynth)
• Cai, J.-C. et al., Alkaloids (N.Y.), 1983, 21, 101, (rev, pharmacol)
• Priel, E., AIDS Res. Hum. Retroviruses, 1991, 7, 65, (anti-HIV activity)
• Curran, D.P. et al., J.A.C.S., 1992, 114, 5863, (synth)
• Wall, M.E. et al., J.A.C.S., 1966, 88, 3888, (isol, uv, ir, pmr, cryst struct)
• Tang, C. et al., J.A.C.S., 1972, 94, 8615, (synth, uv)
• Tang, C.S.F. et al., J.A.C.S., 1975, 97, 159, (synth, uv, pmr)
• Heckendorf, A.H. et al., Tet. Lett., 1977, 4153, (biosynth)
• Earl, R.A. et al., J.O.C., 1984, 49, 4786, (synth)
• Suffness, M. et al., Alkaloids (N.Y.), 1985, 25, 83, (antineoplastic activity)
• Comins, D.L. et al., J.A.C.S., 1992, 114, 10971, (synth)
• Sugasawa, T. et al., Chem. Pharm. Bull., 1974, 22, 77, (synth, ir, pmr)
• Bradley, J.C. et al., J.O.C., 1976, 41, 699, (synth)
• Martindale, The Extra Pharmacopoeia, 28th/29th edn., Pharmaceutical Press, 1982, 12515
• Winterfeldt, E. et al., Angew. Chem., Int. Ed., 1972, 11, 289, (synth)
• Earl, R.A., J.A.C.S., 1983, 105, 6991, (synth)
• Ihara, M. et al., J.O.C., 1983, 48, 3150, (synth)
• Ezell, E.L. et al., J. Nat. Prod., 1991, 54, 1645, (pmr, cmr)