物质信息
ID:449555
名称和标识
IUPAC标准名
1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
别名
CaffeineMethyltheobromineCafipelTheineGuaranineCoffeine
IUPAC传统名
1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
数据登录号
CAS号
化合物性质
产品相关信息
应用领域
Psychotonic
Possesses virucidal props
Widely used CNS, respiratory and cardiac stimulant, main effect on the cerebral cortex
In the horse is used to treat colic, heat stroke, circulatory disturbance and fatigue, also for horse doping
Chemosterilant against stored grain pests.
Psychostimulant
Diuretic
Flavouring ingredient
Used in many beverages
Analeptic
生物来源
Component of coffee beans ( Coffea arabica ), many other Coffea spp., chocolate ( Theobroma cacao ), tea ( Camellia thea ), kolanut ( Cola acuminata ) and several other Cola spp.
and several other plants (Rubiaceae, Sterculiaceae, Theaceae).
Also occurs as a fungal metab. of Claviceps sorghicola
药理学性质
生物活性机理
Modulator of intracellular calcium handling
Inhibitor of cyclic nucleotide phosphodiesterases
Antagonist of adenosine receptors
描述信息
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分子图谱
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参考文献
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• Benowitz, N.L. et al., Annu. Rev. Med., 1990, 41, 277, (rev, pharmacol)
• Parliment, T.H. et al., ACS Symp. Ser., 2000, 754
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 921
• Fischer, E. et al., Ber., 1895, 28, 2473; 3135, (synth)
• Bredereck, H. et al., Chem. Ber., 1950, 83, 201; 1962, 95, 1902, (synth)
• Twanmoh, L.-M. et al., J. Het. Chem., 1973, 10, 187, (pmr)
• Zubair, M.U. et al., Anal. Profiles Drug Subst., 1986, 15, 71, (rev, ir, uv, pmr, cmr, ms, occur, anal)
• IARC Monog., 1991, 51, 291, (rev, tox)
• Sitkowski, J. et al., Spectrochim. Acta A, 1995, 51, 839, (pmr, cmr, N-15 nmr)
• Aldrich Library of NMR Spectra, 2nd edn., 1983, 2, 586A, (nmr)
• Aldrich Library of FT-IR Spectra, 1st edn., 1985, 2, 710B, (ir)
• Caffeine, (ed. Spiller, G.A.), CRC Press, 1998, (book)
• Encyclopedia of Food and Color Additives, (ed. Burdock, G.A.), CRC Press, 1997, 363
• Bogo, A. et al., Phytochemistry, 2000, 54, 937-939, (isol, ms)
• Blout, E.R. et al., J.A.C.S., 1950, 72, 479, (ir)
• Spiteller, G. et al., Monatsh. Chem., 1962, 93, 632, (ms)
• Somani, S.M. et al., Int. J. Clin. Pharmacol., Ther. Toxicol., 1988, 26, 521, (rev)
• Bott, K., Chem. Ber., 1993, 126, 1955, (synth)
• Sutor, D.J., Acta Cryst., 1958, 11, 453, (cryst struct)
• Suzuki, T. et al., Phytochemistry, 1976, 15, 1235, (biosynth)
• Lewis, R.J., Food Additives Handbook, Van Nostrand Reinhold International, New York, 1989, CAK500
• Arnaud, M.J., Prog. Drug Res., 1987, 31, 273, (rev, chem, pharmacol, toxicity)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, CAK500