物质信息
ID:449551
名称和标识
IUPAC标准名
(2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid
IUPAC传统名
(2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid
别名
LarodopaLevopaLevodopaBrocadopaDoparVeldopaBendopa
数据登录号
CAS号
化合物性质
药理学性质
生物活性机理
Decarboxylated into dopamine in the basal ganglia and in the periphery markedly increasing serum dopamine
Dopaminergic
Able to cross the blood-brain-barrier
产品相关信息
应用领域
Antiparkinsonian
生物来源
Occurs in seedlings and pods of Vicia faba , in Mucuna pruriens, Sarothamnus scoparius, Stizolobium deeringianum, Stizolobium hassjoo, Aristolochia clematitis and other plants.
Also prod. by Bacillus spp.
描述信息
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分子图谱
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参考文献
• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 2, 1190A; 1190B, (nmr)
• Fuller, W.D. et al., Biopolymers, 1978, 17, 2939, (polym)
• Danishevsky, S. et al., Tetrahedron, 1981, 37, 4081, (synth)
• Griffith, T. et al., Phytochemistry, 1973, 12, 1651, (biosynth)
• Mostad, A. et al., Acta Chem. Scand., Ser. B, 1974, 28, 1161, (cryst struct)
• Yamamoto, H. et al., Polymer, 1977, 18, 979; 1978, 19, 1115, (polym)
• Nutt, J.G. et al., Clin. Neuropharmacol., 1984, 7, 35, (rev, metab)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 7th edn., Akademie-Verlag, 1994, 1471, (synonyms)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, DNA200
• Fellman, J.H. et al., Biochim. Biophys. Acta, 1975, 381, 9, (isol, deriv)
• Lee, M. et al., Chem. Pharm. Bull., 1987, 35, 235, (hplc, bibl, anal)
• Laycock, M.V. et al., J. Nat. Prod., 1984, 47, 1033, (isol, sulfate)
• Chapman, R.F. et al., J.C.S.(C), 1970, 865, (dimer)
• Aldrich Library of FT-IR Spectra, 1st edn., 1985, 2, 257A; 257B, (ir)
• Vorbruggen, H. et al., Chem. Ber., 1972, 105, 1168, (synth)
• Behrman, E.J. et al., Org. Prep. Proced. Int., 1989, 21, 351, (synth, sulfate)
• Gomez, R. et al., Anal. Profiles Drug Subst., 1976, 5, 189, (rev)
• Renth, E.-O., Angew. Chem., Int. Ed., 1975, 14, 361, (synth)
• Bartholini, G. et al., Pharmacol. Ther., Part B, 1975, 1, 407, (rev, pharmacol)
• Dardenne, G. et al., Phytochemistry, 1977, 16, 1822, (deriv)