物质信息
ID:449547
名称和标识
IUPAC标准名
(2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid
别名
GlycyrrhetinUralenic acidBiosoneGlycyrrhetic acidGlycyrrhetinic acidRhetinic acidEnoxoloneBiogastrone acid
IUPAC传统名
(2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid
数据登录号
CAS号
化合物性质
产品相关信息
应用领域
Used in treatment of noninfective inflammatory disorders (skin, mouth, etc.)
Antibacterial, antitussive agent
Antiinflammatory
生物来源
Aglycone from Glycyrrhiza glabra and some other plants
药理学性质
生物活性机理
Reported to inhibit reactive oxygen species generation by human neutrophils in-vitro
Reported to trap hydroxyl radicals to suppress rat liver injury caused by ischemia-perfusion
Calcium-mobilizer in P815 cells in-vitro
描述信息
暂无数据
点击上传数据
分子图谱
暂无数据
点击上传数据
参考文献
• Robson, J.M. et al., Carbenoxolone Sodium, Orig. Pap. Discuss. Group Meet., Butterworth, London, 1969, (rev)
• Tolstikov, G.A. et al., Khim. Prir. Soedin., 1985, 21, 645; Chem. Nat. Compd. (Engl. Transl.), 1985, 21, 605, (cmr)
• Sakano, K. et al., Agric. Biol. Chem., 1986, 50, 763, (deriv)
• Sandiya, R. et al., J. Het. Chem., 1984, 21, 845, (isol)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 758; 873
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, GIE000; BGD000; GIEO5O; CBO500
• U.K. Pat., 1960, 843 133; CA, 55, 2027i, (Carbenoxolone)
• Beaton, J.M. et al., J.C.S., 1955, 3126, (synth)
• Canonica, L. et al., Gazz. Chim. Ital., 1967, 97, 1347; 1968, 98, 602, (Glycyrrhetol)
• Wahlberg, I. et al., Acta Chem. Scand., 1971, 25, 3192, (ms)
• Mer, J., Am. Perfum. Aromat., 1959, 74, 39, (isol)
• Kanaoka, M. et al., Chem. Pharm. Bull., 1988, 36, 3264, (synth)
• Saito, S. et al., Chem. Pharm. Bull., 1994, 42, 1016, (synth)
• Aldrich Library of FT-IR Spectra, 1st edn., 1985, 2, 1057D, (ir)
• Budzikiewicz, H. et al., J.A.C.S., 1963, 85, 3688, (ms)
• Murav'ev, I.A. et al., CA, 1966, 69, 44029v, (rev)
• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 3, 596A, (nmr)
• Witz, P. et al., Bull. Soc. Chim. Fr., 1963, 1101, (cd)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 7889; 8042, (synonyms)