物质信息
ID:449535
名称和标识
IUPAC标准名
7-(1,3-dioxolan-2-ylmethyl)-1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
别名
AnsimarMaxiventDoxofylline
IUPAC传统名
7-(1,3-dioxolan-2-ylmethyl)-1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
数据登录号
CAS号
化合物性质
药理学性质
生物活性机理
The bronchodilatory effect is due to their ability to inhibit phosphodiesterase (PDE) and thus inhibit breakdown of cAMP (cyclic adenosine monophosphate)
Increase in cyclic AMP inhibits activation of inflammatory cells in addition to bronchodilation
产品相关信息
应用领域
Antitussive agent used for treatment of bronchospasm
描述信息
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分子图谱
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参考文献
• Badini, C. et al., Farmaco, Ed. Sci., 1982, 37, 320, (hplc)
• Bologna, E. et al., J. Int. Med. Res., 1990, 18, 282, (pharmacokinet)
• U.K. Pat., 1978, Instituto Biologico Chemioterapico ABC, 1 582 510; CA, 90, 197858y, (pharmacol)
• Franzone, J.S. et al., Farmaco, Ed. Sci., 1981, 36, 220, (metab)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, TEQ175
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 1317