物质信息
ID:449483
名称和标识
IUPAC标准名
2-[4-(2-methylpropyl)phenyl]propanoic acid
别名
BrufenMotrinNurofenIbuprofenCodafenPaxofenFemafen; ProflexLidifenLobufenApsifenEbufac
IUPAC传统名
2-[4-(2-methylpropyl)phenyl]propanoic acid
数据登录号
CAS号
化合物性质
产品相关信息
应用领域
Analgesic
Non-steroidal antiinflammatory agent
Antipyretic
药理学性质
生物活性机理
Cyclooxygenase (COX) inhibitor
Prostaglandin antagonist
描述信息
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分子图谱
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参考文献
• Hiyama, T. et al., Synthesis, 1986, 645, (synth)
• Kaiser, D.G. et al., J. Pharm. Sci., 1976, 65, 269, (resoln, glc, bibl)
• Nicoll-Griffith, D.A., J. Chromatogr., 1987, 402, 179, (resoln)
• Eur. Pat., 1988, Gist-Brocades; Shell Int. Res., 274 146; CA, 110, 113203, (dexibuprofen lysine)
• Shankland, N. et al., Acta Cryst. C, 1997, 53, 951-954, (cryst struct)
• McConnell, J.F., Cryst. Struct. Commun., 1974, 3, 73, (cryst struct)
• Davies, N.M. et al., Clin. Pharmacokinet., 1998, 34, 101-154, (rev)
• U.K. Pat., 1964, 971 700; CA, 61, 14591, (synth, pharmacol)
• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 2, 1011B, (nmr)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 2867, (synonyms)
• Gonzalez, A., Synth. Commun., 1991, 21, 1353, (synth)
• Nicholson, J.S., Chron. Drug Discovery, 1982, 1, 149, (rev)
• Freer, A.A., Acta Cryst. C, 1993, 49, 1378, (cryst struct)
• Lalonde, J.J. et al., J.A.C.S., 1995, 117, 6845, (resoln)
• Higgins, J.D. et al., Anal. Profiles Drug Subst., 2001, 27, 265-300, (rev)
• Ghislandi, V. et al., Farmaco, Ed. Sci., 1982, 37, 81, (abs config)
• Gruber, K. et al., Arzneim.-Forsch., 1983, 33, 1176, (pharmacol, tox)
• Sonawane, H.R. et al., Tetrahedron, 1994, 50, 1243, (synth)
• Adams, S.S. et al., Arch. Int. Pharmacodyn. Ther., 1969, 178, 115
• Adams, S.S. et al., Toxicol. Appl. Pharmacol., 1969, 15, 310, (metab, tox)
• Ger. Pat., 1975, 2 508 895; CA, 84, 5394, (lysine, salt)
• Yamauchi, T. et al., Synthesis, 1986, 1044, (synth)
• Martindale, The Extra Pharmacopoeia, 31st edn., Pharmaceutical Press, 1996, 50
• Shiori, T. et al., J.O.C., 1978, 43, 2936, (synth)
• Wolber, E.K.A. et al., Chem. Ber., 1991, 124, 1667, (synth, pmr)