物质信息

ID:449220

名称和标识
IUPAC标准名
2-hydroxy-3-[(1r,4r)-4-(4-chlorophenyl)cyclohexyl]-1,4-dihydronaphthalene-1,4-dione
别名
MepronAtovaquoneMalarone
IUPAC传统名
2-hydroxy-3-[(1r,4r)-4-(4-chlorophenyl)cyclohexyl]-1,4-dihydronaphthalene-1,4-dione
数据登录号
化合物性质
药理学性质
生物活性机理
The ultimate metabolic effects of such blockade may include inhibition of nucleic acid and ATP synthesis.
Inhibition of electron transport by atovaquone will result in indirect inhibition of these enzymes.
In Plasmodium species, the site of action appears to be the cytochrome bc1 complex (Complex III).
The mechanism of action against Pneumocystis carinii has not been fully elucidated
Several metabolic enzymes are linked to the mitochondrial electron transport chain via ubiquinone.
产品相关信息
应用领域
Antiprotozoal
Orally active antiprotozoal used for treatment of AIDS-associated pneumonia
Antiparasitic agent
Active (in animals and in vitro) against Pneumocystis carinii, Plasmodia, and tachyzoite and cyst forms of Toxoplasma gondii
描述信息
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参考文献
• Falloon, J. et al., N. Engl. J. Med., 1991, 325, 1534, (use)
• DeAngelis, D.V. et al., J. Chromatogr., 1994, 652, 211, (hplc)
• Haile, L.G. et al., Ann. Pharmacother., 1993, 27, 1488, (rev)
• Eur. Pat., 1984, Wellcome, 123 238; CA, 102, 113082w, (synth, pharmacol)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 510
• Hudson, A.T., Parasitol. Today, 1993, 9, 66, (rev)
• Hughes, W.T. et al., Antimicrob. Agents Chemother., 1990, 34, 225, (pharmacol)
• Aranjo, F.G. et al., Antimicrob. Agents Chemother., 1991, 35, 293, (pharmacol)
• Drugs of Today (Barcelona), 1993, 29, 243, (rev)
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