物质信息
ID:449195
名称和标识
IUPAC标准名
6-(trifluoromethoxy)-1,3-benzothiazol-2-amine
别名
RilutekRiluzole
IUPAC传统名
6-(trifluoromethoxy)-1,3-benzothiazol-2-amine
数据登录号
CAS号
化合物性质
药理学性质
生物活性机理
Glutamate transporter activation
Sodium channel blockade
High-voltage calcium channel blockade
N-methyl-D-aspartate (NMDA)/glutamate receptor antagonism
产品相关信息
应用领域
Used in treatment of amyotrophic lateral sclerosis
Anticonvulsant, antiepileptic agent
描述信息
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分子图谱
暂无数据
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参考文献
• Rowland, L.P., N. Engl. J. Med., 1994, 330, 636
• Mantz, J., CNS Drug Rev., 1996, 2, 40, (rev)
• Yagupol'skii, L.M. et al., Zh. Obshch. Khim., 1963, 33, 2301, (synth)
• Tsai, C. et al., Neurol. Neurobiol., 1987, 24, 79, (pharmacol)
• Eur. Pat., 1982, Pharmindustrie, 50 551; CA, 97, 44352, (pharmacol)
• Bensimon, G. et al., N. Engl. J. Med., 1994, 330, 585, (clin trial)
• Mizoule, J. et al., Neuropharmacology, 1985, 24, 767, (pharmacol)
• Mantz, J. et al., Eur. J. Pharmacol., 1994, 257, R7, (pharmacol)