物质信息
ID:449193
名称和标识
别名
ReserpineSerpasilApoplonReserpoidSermixSandrilCarpacil
IUPAC标准名
methyl (1R,15S,17R,18R,19S,20S)-6,18-dimethoxy-17-(3,4,5-trimethoxybenzoyloxy)-3,13-diazapentacyclo[11.8.0.02,10.04,9.015,20]henicosa-2(10),4,6,8-tetraene-19-carboxylate
IUPAC传统名
methyl (1R,15S,17R,18R,19S,20S)-6,18-dimethoxy-17-(3,4,5-trimethoxybenzoyloxy)-3,13-diazapentacyclo[11.8.0.02,10.04,9.015,20]henicosa-2(10),4,6,8-tetraene-19-carboxylate
数据登录号
CAS号
化合物性质
产品相关信息
应用领域
Antiadrenergic
Antineoplastic agent
Antihypertensive agent acting by depleting stores of noradrenaline in sympathetic neurones
Anticonvulsant agent
Possesses sedative tranquilliser props.
生物来源
Alkaloid from Rauwolfia serpentina, Rauwolfia vomitoria, Rauwolfia macrophylla , very many other Rauwolfia spp., Vinca minor, Alstonia constricta and many other spp. in the Apocynaceae,
e.g. Tenduzia longifolia, Vallesia dichotoma and Excavatia coccinea
药理学性质
生物活性机理
Disruption of norepinephrine, serotonin, and dopamine presynaptic vesicles by the transporter VMAT
描述信息
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分子图谱
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参考文献
• Furlenmeyer, A. et al., Experientia, 1953, 9, 331, (uv, ir)
• Bein, H.J., Handb. Exp. Pharmacol., (Part 1), 1980, 55, 43-58, (rev, pharmacol)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 7993, (synonyms)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 343; 386
• Taylor, W.I. et al., The Vinca Alkaloids, Marcel Dekker, 1973, (rev, props)
• Becker, O. et al., Org. Mass Spectrom., 1977, 12, 461, (ms)
• Szntay, C. et al., Alkaloids (N.Y.), 1986, 27, 253, (pharmacol, bibl)
• Nicolaou, K.C. et al., Classics in Total Synthesis, Targets, Strategies, Methods, VCH, 1996, 55, (bibl, synth)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, DIG800; DIH000; RDK000
• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 3, 615A, (nmr)
• Ban, Y. et al., Tetrahedron, 1964, 20, 2877, (config)
• Wender, P.A. et al., J.A.C.S., 1980, 102, 6157, (synth)
• Chu, C.S. et al., Chem. Comm., 1996, 1537, (synth)
• Aldrich Library of FT-IR Spectra, 1st edn., 1985, 2, 1069C, (ir)
• Levin, R.H. et al., J.O.C., 1973, 38, 1983, (cmr)
• IARC Monog., 1980, 24, 211; Suppl., 6, 485; Suppl., 7, 330, (rev, tox)
• Muhtadi, F.J., Anal. Profiles Drug Subst., 1984, 13, 737, (rev, ir, pmr, cmr, ms, anal)
• Lounasmaa, M. et al., Heterocycles, 1985, 23, 371, (pmr)
• Martin, S.F. et al., J.A.C.S., 1987, 109, 6124, (synth)
• Hanessian, S. et al., J.O.C., 1997, 62, 465, (synth)
• Velluz, L. et al., Bull. Soc. Chim. Fr., 1958, 145; 673, (synth)
• Woodward, R.B. et al., Tetrahedron, 1958, 2, 1, (synth)
• Schlittler, E., Alkaloids (N.Y.), 1965, 8, 287, (rev)
• Pearlman, B.A., J.A.C.S., 1979, 101, 6404, (synth)
• Stork, G., Pure Appl. Chem., 1989, 61, 439, (synth)