物质信息
ID:449179
名称和标识
别名
OrnidazoleBiteralDanubialMadelenTibalOrnidalTiberalTinerolBetiralKolpicid
IUPAC标准名
1-chloro-3-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-ol
IUPAC传统名
1-chloro-3-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-ol
数据登录号
CAS号
化合物性质
产品相关信息
应用领域
Antiprotozoal agent
Active against anaerobic bacteria
药理学性质
生物活性机理
Interacts with DNA to cause a loss of helical DNA structure and strand breakage resulting in inhibition of protein synthesis and cell death in susceptible organisms
描述信息
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分子图谱
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参考文献
• Hoffer, M. et al., J. Med. Chem., 1974, 17, 1019, (synth, pharmacol)
• Chen, B.C. et al., Helv. Chim. Acta, 1983, 66, 1537, (N-15 nmr)
• Nagarajan, K. et al., Indian J. Chem., Sect. B, 1982, 21, 1006, (cmr, pmr, uv, ms)
• Martindale, The Extra Pharmacopoeia, 31st edn., Pharmaceutical Press, 1996, 626
• McClain, R.M. et al., Toxicol. Appl. Pharmacol., 1988, 92, 488, (tox)
• Yeung, C.H. et al., J. Reprod. Fertil., 1995, 103, 257; 1996, 106, 231, (tox)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, OJS000