物质信息
ID:449177
名称和标识
别名
PatadayPatanaseOpatanolOlopatadine HydrochloridePatanol SPatanol
IUPAC传统名
2-[(2Z)-2-[3-(dimethylamino)propylidene]-9-oxatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-5-yl]acetic acid hydrochloride
IUPAC标准名
2-[(2Z)-2-[3-(dimethylamino)propylidene]-9-oxatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-5-yl]acetic acid hydrochloride
数据登录号
CAS号
化合物性质
药理学性质
生物活性机理
Histamine H1-receptor antagonist,
Mediator release inhibitor
产品相关信息
应用领域
Used in the treatment of allergic rhinitis, urticaria, allergic conjunctivitis and asthma
Antiallergic agent
成盐信息
HCl
描述信息
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分子图谱
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参考文献
• Eur. Pat., 1987, Kyowa Hakko Kogyo, 235 796; CA, 108, 167330, (synth, pharmacol)
• Berdy, G.J. et al., Clin. Ther., 2000, 22, 826-833; 2001, 23, 1272-1280, (pharmacol)
• Ikemura, T. et al., Int. Arch. Allergy Appl. Immunol., 1996, 110, 57; 64, (pharmacol)
• Ikeda, K. et al., Int. Arch. Allergy Appl. Immunol., 1995, 106, 157, (pharmacol)
• Sharif, N.A. et al., J. Pharmacol. Exp. Ther., 1996, 278, 1252, (pharmacol)
• Oshima, E. et al., J. Med. Chem., 1992, 35, 2074, (synth, cryst struct, pharmacol)