物质信息
ID:449175
名称和标识
别名
AnandronNilandronNilutamide
IUPAC标准名
5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]imidazolidine-2,4-dione
IUPAC传统名
5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]imidazolidine-2,4-dione
数据登录号
CAS号
化合物性质
产品相关信息
应用领域
Used for treatment of prostatic cancer
Antineoplastic agent
药理学性质
生物活性机理
Androgen receptor blocker, preventing its interaction with testosterone
描述信息
暂无数据
点击上传数据
分子图谱
暂无数据
点击上传数据
参考文献
• Decensi, A. et al., Eur. J. Cancer, 1991, 27, 1100, (clin trial)
• Harris, M.G. et al., Drugs Aging, 1993, 3, 9, (rev)
• Moguilewsky, M. et al., J. Steroid Biochem., 1987, 27, 871, (rev, pharmacol)
• Ojasoo, T., Drugs of the Future, 1987, 12, 763, (rev)
• Raynaud, J.P. et al., Prog. Clin. Biol. Res., 1985, 185A, 99, (rev, pharmacol)
• Moguilewsky, M. et al., Prog. Cancer Res. Ther., 1988, 35, 349, (rev, activity)
• Ger. Pat., 1977, Roussel, 2 649 925; CA, 87, 85005, (synth)
• Dhar, J.D. et al., Contraception, 1990, 42, 121, (tox)
• Gomez, J.-L. et al., Am. J. Med., 1992, 92, 563, (tox)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 496
• Berson, A. et al., J. Pharmacol. Exp. Ther., 1994, 270, 167, (tox)
• Pendyala, L. et al., Cancer Chemother. Pharmacol., 1988, 22, 69, (metab)