物质信息
ID:449174
名称和标识
别名
NicergolineSermionNargolineNimergolineNicotergoline
IUPAC标准名
[(2S,4R,7R)-2-methoxy-6,11-dimethyl-6,11-diazatetracyclo[7.6.1.02,7.012,16]hexadeca-1(16),9,12,14-tetraen-4-yl]methyl 5-bromopyridine-3-carboxylate
IUPAC传统名
[(2S,4R,7R)-2-methoxy-6,11-dimethyl-6,11-diazatetracyclo[7.6.1.02,7.012,16]hexadeca-1(16),9,12,14-tetraen-4-yl]methyl 5-bromopyridine-3-carboxylate
数据登录号
CAS号
化合物性质
药理学性质
生物活性机理
Cholinergic
a1-Adrenoceptor antagonist
Peripheral vasodilator
Calcium channel antagonist
产品相关信息
应用领域
Cerebroprotective props
Has been used in treatment of senile dementia
描述信息
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分子图谱
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参考文献
• Sioufi, A. et al., Biomed. Chromatogr., 1992, 6, 9, (hplc, metab)
• Bernardi, L. et al., Farmaco, Ed. Sci., 1975, 30, 789, (synth, pharmacol)
• Martindale, The Extra Pharmacopoeia, 31st edn., Pharmaceutical Press, 1996, 1731
• Neumann, B.W. et al., Arzneim.-Forsch., 1979, 29, 1206, (numerous papers)
• Fumagalli, M. et al., Contact Dermatitis, 1992, 27, 256
• Carfagna, N. et al., Neurosci. Lett., 1995, 197, 195, (pharmacol)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, NDM000
• Takahashi, K. et al., Br. J. Pharmacol., 1990, 100, 705, (pharmacol)
• Arrigo, A. et al., Int. J. Clin. Pharmacol. Res., Suppl. 1, 1982, 11, 33, (use)
• Shintomi, K. et al., J. Pharmacobio-Dyn., 1987, 10, 35, (pharmacol, tox)
• Banno, K. et al., J. Chromatogr., 1991, 568, 375, (hplc)
• Arcari, G. et al., Experientia, 1972, 28, 819
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 7056, (synonyms)