物质信息
ID:449155
名称和标识
IUPAC标准名
5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid
别名
LopidGemcorGemfibrozilLipozidLipurOrganolipidHipolixanEmfib
IUPAC传统名
5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid
数据登录号
CAS号
化合物性质
产品相关信息
应用领域
Antihyperlipidaemic drug
药理学性质
生物活性机理
Increases activity of Peroxisome proliferator-activated receptor-alpha (PPAR-alpha)
描述信息
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分子图谱
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参考文献
• Todd, P.A. et al., Drugs, 1988, 36, 314, (rev)
• Alegret, M. et al., Br. J. Pharmacol., 1995, 114, 1351, (pharmacol)
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 1273
• U.S. Pat., 1979, 4 126 637; CA, 90, 121021z, (synth)
• Peroxisomes: Biology and Importance in Toxicology and Medicine, (Eds. Gibson, G. et al), Taylor and Francis, 1993, (tox)
• Barter, P.J., J. Drug Eval. Cardiovasc. Med., 2002, 1, 13-39, (rev)
• U.S. Pat., 1973, 3 707 566; CA, 78, 58105q, (synth)
• Glueck, C., Am. J. Cardiol., 1983, 52, 31, (rev)
• Creger, P.L. et al., Proc. R. Soc. Med., (Suppl. 2), 1976, 69, 1, (pharmacol, metab, tox)
• Zimetbaum, P. et al., J. Clin. Pharmacol., 1991, 31, 25, (pharmacol, rev)
• Spencer, C.M. et al., Drugs, 1996, 51, 982, (rev, pharmacol)
• Abraham, D.J. et al., J. Med. Chem., 1984, 27, 967, (synth, props)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 7th edn., Akademie-Verlag, 1994, 4802, (synonyms)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, GCK300