物质信息
ID:449148
名称和标识
IUPAC标准名
2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol
别名
DiflucanElazorTriflucanBiozoleneFluconazoleFungata
IUPAC传统名
2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol
数据登录号
CAS号
化合物性质
产品相关信息
应用领域
Antifungal agent
Effective in single oral dose against vaginal candidiasis
Not active against Aspergillus
Prophylactic treatment for AIDS patients
药理学性质
生物活性机理
Inhibitor of fungal cytochrome P450 enzyme 14alpha-demethylase
描述信息
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分子图谱
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参考文献
• Cobos Garcia, F.J. et al., Farm. Clin., 1991, 8, 423, (rev)
• U.K. Pat., 1982, Pfizer, 2 099 818; CA, 99, 38467q, (synth, pharmacol)
• Urbak, S.F. et al., Ophthalmologica, 1994, 208, 147, (use, rev)
• Pat. Coop. Treaty (WIPO), 1997, Pfizer, 97 28 169; CA, 127, 220800s, (fosfluconazole, synth, pharmacol)
• Fluconazole, (Eds., Powderly, W.G. et al), Marius Press, 1992, (book)
• Morck, H., Pharm. Ztg., 1991, 136, 56; 60, (rev)
• Morita, K. et al., Chem. Pharm. Bull., 1992, 40, 1247, (pharmacol)
• Grant, S.M. et al., Drugs, 1990, 39, 877, (rev)
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 378
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 7th edn., Akademie-Verlag, 1994, 3349, (synonyms)
• Goa, K.L. et al., Drugs, 1995, 50, 658, (rev, pharmacokinet)