物质信息
ID:449114
名称和标识
IUPAC标准名
(2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid
别名
SoriataneAcitretinNeotigasonEtretin
IUPAC传统名
(2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid
数据登录号
CAS号
化合物性质
产品相关信息
应用领域
Used for treatment of psoriasis, antineoplastic agent
Active against epithelial tumours
药理学性质
生物活性机理
Second generation retinoid
描述信息
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分子图谱
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参考文献
• Pilkington, T. et al., Drugs, 1992, 43, 597, (rev)
• Haenni, R. et al., Helv. Chim. Acta, 1977, 60, 2309, (synth, pmr, ms, metab)
• Coffey, J.W. et al., Int. Congr. Ser. Excerpta Med., 1987, 750, 705, (rev, isomers)
• Jakobsen, P. et al., J. Chromatogr., 1987, 415, 413, (hplc)
• Mayer, H. et al., Experientia, 1978, 34, 1105, (rev, pharmacol)
• Ward, A. et al., Drugs, 1983, 26, 9, (rev)
• Bestmann, H.J. et al., Annalen, 1984, 1740, (isoetretin)
• Paravicini, U. et al., Ann. N.Y. Acad. Sci., 1981, 359, 54, (rev, metab)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, EMJ500; REP400
• Cunliffe, W.J., Biochem. Soc. Trans., 1986, 14, 943, (props)
• Bouvy, M.L. et al., Pharm. Weekbl., Sci. Ed., 1992, 14, 33, (Acitretin, rev, pharmacokinet)
• Ger. Pat., 1977, 2 636 879; CA, 87, 23565y, (synth, deriv)
• Englert, G. et al., Helv. Chim. Acta, 1978, 61, 2697, (pmr, isom)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 754; 758