物质信息
ID:4477
名称和标识
别名
TX52219-nor-14-epi-23-yne-1,25 dihydroxyvitamin D3
IUPAC传统名
(1R,3S,5Z)-5-{2-[(1R,3aR,4Z,7aR)-1-[(2R)-6-hydroxy-6-methylhept-4-yn-2-yl]-7a-methyl-hexahydro-1H-inden-4-ylidene]ethylidene}-4-methylidenecyclohexane-1,3-diol
IUPAC标准名
(1R,3S,5Z)-5-{2-[(1R,3aR,4Z,7aR)-1-[(2R)-6-hydroxy-6-methylhept-4-yn-2-yl]-7a-methyl-octahydro-1H-inden-4-ylidene]ethylidene}-4-methylidenecyclohexane-1,3-diol
化合物性质
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描述信息
Drug Groups
experimental
Indication
Investigated for use/treatment in prostate cancer, psoriasis and hyperparathyroidism.
References
•
Wong MS, Delansorne R, Man RY, Vanhoutte PM: Vitamin D derivatives acutely reduces endothelium-dependent contractions in the aorta of the spontaneously hypertensive rat. Am J Physiol Heart Circ Physiol. 2008 May 16;.
[Pubmed]
•
Eelen G, Verlinden L, Van Camp M, Claessens F, De Clercq P, Vandewalle M, Bouillon R, Verstuyf A: Altered Vitamin D receptor-coactivator interactions reflect superagonism of Vitamin D analogs. J Steroid Biochem Mol Biol. 2005 Oct;97(1-2):65-8. Epub 2005 Jul 20.
[Pubmed]
•
Company Website
[Link]
分子图谱
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参考文献
• Wong MS, Delansorne R, Man RY, Vanhoutte PM: Vitamin D derivatives acutely reduces endothelium-dependent contractions in the aorta of the spontaneously hypertensive rat. Am J Physiol Heart Circ Physiol. 2008 May 16;. Pubmed
• Company Website Link
• Eelen G, Verlinden L, Van Camp M, Claessens F, De Clercq P, Vandewalle M, Bouillon R, Verstuyf A: Altered Vitamin D receptor-coactivator interactions reflect superagonism of Vitamin D analogs. J Steroid Biochem Mol Biol. 2005 Oct;97(1-2):65-8. Epub 2005 Jul 20. Pubmed