物质信息
ID:4281
名称和标识
IUPAC标准名
1-benzyl-1H-imidazole
别名
N-Benzylimidazole1-Benzyl-1H-imidazoleBIM1-benzylimidazole
IUPAC传统名
1-benzylimidazole
化合物性质
理化性质
疏水性(logP)
1.60 [AVDEEF,A (1993)]
描述信息
Drug Groups
experimental
Description
1-benzylimidazole, an N-imidazole derivative, has been shown to have strong cardiotonic activity.
Affected Organisms
Humans and other mammals
References
•
Mori Y, Iimura K, Hirano K: N-benzylimidazole, a potent inducer of rat liver enzymes involved in mutagenic activation of various carcinogens. Mutat Res. 1993 Jun;302(2):129-33.
[Pubmed]
•
Lucas J, Chan PS, Mateja N, Cervoni P, Ronsberg MA, Lipchuck LM: 1-Benzylimidazole, a thromboxane synthetase inhibitor acutely lowers blood pressure mainly by alpha-adrenoceptor blockade in spontaneously hypertensive rats (SHR). Prostaglandins Leukot Med. 1983 Dec;12(4):409-21.
[Pubmed]
•
Tuttle RS, Garcia-Minor C, Simon M: Cardiovascular effects of 1-benzylimidazole. J Pharmacol Exp Ther. 1975 Sep;194(3):624-32.
[Pubmed]
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参考文献
• Lucas J, Chan PS, Mateja N, Cervoni P, Ronsberg MA, Lipchuck LM: 1-Benzylimidazole, a thromboxane synthetase inhibitor acutely lowers blood pressure mainly by alpha-adrenoceptor blockade in spontaneously hypertensive rats (SHR). Prostaglandins Leukot Med. 1983 Dec;12(4):409-21. Pubmed
• Tuttle RS, Garcia-Minor C, Simon M: Cardiovascular effects of 1-benzylimidazole. J Pharmacol Exp Ther. 1975 Sep;194(3):624-32. Pubmed
• Mori Y, Iimura K, Hirano K: N-benzylimidazole, a potent inducer of rat liver enzymes involved in mutagenic activation of various carcinogens. Mutat Res. 1993 Jun;302(2):129-33. Pubmed