物质信息
ID:397944
名称和标识
别名
ZarnestraTipifarnib(R)-(+)-R 1157776-[(R)-Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone
IUPAC标准名
6-[(R)-amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-1,2-dihydroquinolin-2-one
IUPAC传统名
tipifarnib
数据登录号
CAS号
化合物性质
理化性质
熔点
211-213°C (dec.)
溶解度
Methanol
Chloroform
外观
Off-White to Pale Beige Solid
安全信息
保存条件
-20°C Freezer
MSDS下载
产品相关信息
质检报告
描述信息
A farnesyltransferase inhibitor. Sensitizes human multiple myeloma cell to proteasome inhibition by blocking degradation of bortezomib(B675700)-induced aggresomes. Also shown to inhibit the growth of myeloid leukemia cell lines and primary leukemia cells
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参考文献
• Nagai, T., et al.: Leukemia Res., 34, 1057 (2010)
• Hong, D., et al.: Clin. Cancer Res., 15, 7061 (2009)
• David, E., et al.: Blood, 116, 5285 (2010)