物质信息
ID:395980
名称和标识
别名
Pyrimido[1,2-a]purin-10(3H)-oneM1GPyrimido[1,2-a]purin-10(1H)-one
IUPAC传统名
3H-pyrimido[1,2-a]purin-10-one
IUPAC标准名
3H,10H-pyrimido[1,2-a]purin-10-one
数据登录号
CAS号
描述信息
M1G is a secondary DNA damage product arising from primary reactive oxygen species (ROS) damage to membrane lipids or deoxyribose. It is a guanine adduct formed by reaction of malondialdehyde with DNA.
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参考文献
• Ham, A., et al.: Chem. Res. Toxicol., 13, 1243 (2000)
• Jeong, Y., et al.: Chem. Res. Toxicol., 18, 51 (2000)
• Sharma, R., et al.: Clin. Cancer Res., 7, 1452 (2000)