物质信息
ID:395413
名称和标识
IUPAC传统名
N-(3-{5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl}-2,4-difluorophenyl)propane-1-sulfonamide
IUPAC标准名
N-(3-{5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl}-2,4-difluorophenyl)propane-1-sulfonamide
别名
PLX-4720N-[3-[(5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide
数据登录号
CAS号
描述信息
PLX4720 is a selective inhibitor of mutant B-RAF and its analog, PLX4032, is currently undergoing clinical trials in melanoma. An antitumor agent.
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参考文献
• Conner, S., et al.: J. Biol. Chem., 278, 34548 (2003)
• Salerno, P., et al.: J. Clin. Endocrinol. Metab., 95, 450 (2003)
• Dumaz, N., et al.: Cancer Res., 66, 9483 (2003)