物质信息
ID:395271
名称和标识
IUPAC标准名
1-{1-[4,4-bis(4-fluorophenyl)butyl]piperidin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one
IUPAC传统名
pimozide
别名
Pimozide1-[1-[4,4-Bis(4-fluorophenyl)butyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-oneR 6238NSC 170984OrapPrimozide1-[1-[4,4-Bis(p-fluorophenyl)butyl]-4-piperidyl]-2-benzimidazolinone1-[4,4-Bis(p-fluorophenyl)butyl]-4-(2-oxo-1-benzimidazolinyl)piperidine
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CAS号
描述信息
Pimozide is a D2 dopamine receptor antagonist. Pimozide binds with high affinity to the cloned 5-HT7 receptor. Pimozide is also a Ca2+ channel antagonist. Pimozide is used as an antipsychotic.
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参考文献
• Liu, J., et al.: Br. J. Pharmacol., 126, 245 (1999)
• Richelson, E., et al.: Life Sci., 68, 29 (1999)
• Santi, C., et al.: J. Neurosci., 22, 396 (1999)
• Mariot, P., et al.: J. Biol. Chem., 277, 10824 (1999)
• Nikonenko, I., et al.: Mol. Pharmacol., 68, 84 (2