物质信息
ID:394566
名称和标识
IUPAC标准名
3-[(dimethylamino)methyl]-N-{2-[4-(hydroxycarbamoyl)phenoxy]ethyl}-1-benzofuran-2-carboxamide
别名
PCI-24781CRA 247813-[(Dimethylamino)methyl]-N-[2-[4-[(hydroxyamino)carbonyl]phenoxy]ethyl]-2-benzofurancarboxamideCRA 024781
IUPAC传统名
abexinostat
数据登录号
CAS号
描述信息
PCI-24781 is a novel hydroxamic acid HDAC inhibitor (histone deacetylase inhibitor). PCI-24781 exerts cytotoxicity and histone H3 alterations via caspase-8 and FADD in leukemia cells.
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参考文献
• Morales, V., et al.: Mol. Cell Biol., 20, 7230 (2000)
• Esteller, M., et al.: Carcinogenesis, 27, 1121 (2000)
• Th'ng, J., et al.: J. Biol. Chem., 280, 27809 (2000)