物质信息
ID:390266
名称和标识
IUPAC传统名
[4-amino-2-(methylsulfanyl)pyrimidin-5-yl]methanol
IUPAC标准名
[4-amino-2-(methylsulfanyl)pyrimidin-5-yl]methanol
别名
4-Amino-2-methylthio-5-pyrimidinemethanol2-Methylmercapto-4-amino-5-hydroxymethylpyrimidineNSC 3431NSC 43811Methioprim(4-Amino-2-methanethiopyrimidin-5-yl)methanol4-Amino-2-methylmercapto-5-pyrimidinemethanol
数据登录号
CAS号
描述信息
An intermediate used in the synthesis of Thiamine (T344185). Also, used for the preparation of pyridopyrimidines and naphthyridines as inhibitors of Akt kinase for the treatment of cancer.
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参考文献
• Breitenlechner, C., et al.: J. Med. Chem., 47, 1375 (2001)
• Zinda, M., et al.: Clin. Cancer Res., 7, 2475 (2001)
• Zhao, Z., et al.: Bioorg. Med. Chem. Lett., 18, 49 (2001)