物质信息
ID:389107
名称和标识
IUPAC传统名
ispinesib
IUPAC标准名
N-(3-aminopropyl)-N-[(1R)-1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl]-4-methylbenzamide
别名
N-(3-Aminopropyl)-N-[(1R)-1-[7-chloro-3,4-dihydro-4-oxo-3-(phenylmethyl)-2-quinazolinyl]-2-methylpropyl]-4-methylbenzamideSB 715992Ispinesib
数据登录号
CAS号
描述信息
Ispinesib is the first potent, highly specific small-molecule inhibitor of KSP tested for the treatment of human disease. Anticancer agent.
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参考文献
• Blangy, A., et al.: J. Biol. Chem., 272, 19418 (1997)
• Sakowicz, R., et al.: Cancer Res., 64, 3276 (1997)
• Kapitein, L., et al.: Nature, 435,
• Wood, K., et al.: Curr. Opin. Pharmacol., 1, 370 (1997)
• Cochran, J., et al.: J. Biol. Chem., 280, 12658 (1997)