物质信息
ID:388894
名称和标识
别名
IsoniazidIsonicotinic acid hydrazide4-PyridylcarbonylhydrazideSauterazidTubazid4-Pyridinecarboxylic HydrazideAtcotibineIsozideZinadonArmazideIsotebezidZonazide4-Pyridinecarboxylic Acid Hydrazide4-Pyridinecarbonylhydrazine4-(Hydrazinocarbonyl)pyridine5015 R.P.IsonizideRobisellinArmazid
IUPAC传统名
isoniazid
IUPAC标准名
pyridine-4-carbohydrazide
数据登录号
CAS号
描述信息
Antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Selectively induces expression of CYP2E1. Reversibly inhibi
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参考文献
• Weber, W.W., et al.: Clin. Pharmacokinet., 4, 401 (1979)
• Brewer, G.A., et al.: Anal. Profiles Drug Subs., 6, 183 (1977)