物质信息
ID:386407
名称和标识
IUPAC标准名
4-methyl-5-{[(2S)-2-methyl-1,4-diazepan-1-yl]sulfonyl}isoquinoline
IUPAC传统名
4-methyl-5-[(2S)-2-methyl-1,4-diazepan-1-ylsulfonyl]isoquinoline
别名
H-1152 Dihydrochloride5-[[(2S)-Hexahydro-2-methyl-1H-1,4-diazepin-1-yl]sulfonyl]-4-methylisoquinoline Hydrochloride(S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolynyl)sulfonyl]Homopiperazine Dihydrochloride
数据登录号
CAS号
化合物性质
安全信息
保存条件
Hygroscopic, -20°C Freezer, Under Inert Atmosphere
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理化性质
外观
White to Off-White Solid
熔点
182-184°C
溶解度
Water
Methanol
产品相关信息
质检报告
描述信息
ROCK Inhibitor. A cell-permeable isoquinolinesulfonamide compound that acts as a highly specific, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase (ROCK: Ki=1.6nM). Exhibits a much weaker affinity for other serine/threonine kina
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参考文献
• Sasaki, Y., et al.: Pharmacol. Ther., 93, 225 (2002)
• Ikenoya, M., et al.: J. Neurochem., 81, 9 (2002)